2. (noun)irritation, annoyance, vexation, botheration the psychological state of being irritated or annoyed
3. (noun)concern, worry, headache, vexation something or someone that causes anxiety; a source of unhappiness "New York traffic is a constant concern"; "it's a major worry"
4. (noun)annoyance, annoying, irritation, vexation the act of troubling or annoyingsomeone