1. (verb) botch, bodge, bumble, fumble, botch up, muff, blow, flub, screw up, ball up, spoil, muck up, bungle, fluff, bollix, bollix up, bollocks, bollocks up, bobble, mishandle, louse up, foul up, mess up, fuck up
make a mess of, destroy or ruin
Synonyms: vitiate, stammer, mud, plunder, impair, drift, pamper, hot up, flub, suck, featherbed, mar, gasconade, squander, ruffle up, boast, heat up, vaunt, itch, screw up, ball up, mire, frustrate, corrupt, bluster, gas, deflower, spoil, muck up, rape, tease, grope, violate, bollocks, mollycoddle, bungle, queer, bollocks up, fumble, muck, shove along, shove off, foil, stutter, blow, bollix, rumple, fuck up, coddle, cosset, shoot a line, scotch, go bad, ruffle, baby, cross, louse up, fellate, float, botch up, bodge, mess up, brag, bobble, baffle, muff, be adrift, fluff, mess, mishandle, tout, foul up, swash, blunder, indulge, despoil, waste, go down on, stumble, blow out, bollix up, botch, thwart, bilk, bumble, falter, cocker, burn out, misconduct, mismanage
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Synonyms and Antonyms of louse up 
