Synonyms for down-and-out
ˈdaʊn əndˈaʊt, -əndown-and-out

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1. down-and-outadjective

   a person who is destitute

   "he tried to help the down-and-out"

   Antonyms:
   successful

2. down-and-outadjective

   lacking resources (or any prospect of resources)

   Antonyms:
   successful

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How to use down-and-out in a sentence?

1. Amy Robbins:

   We are so inundated with so much fear-based information at this time that I want to have control over what I am putting into my mind. I am always listening to something that helps me learn and grow and feel good about myself, everyone is feeling upside down and out of control right now, so it is extremely important to focus on the parts of your life that you have some control over to give your foundation a bit of sturdiness.

2. Orson Welles:

   When you are down and out something always turns up-and it is usually the noses of your friends.

3. Stephen Murray:

   I used to say for 31 years, another day in Paradise. And I haven't said that in a while, i'm depressed, I'm down and out, all I want to do is to have my job back. I want to have my life back.

4. Justin Ihle:

   There are many more important things in this world than a stuffed an animal, but the outpouring of support has been amazing, william is not totally down-and-out ? he’s a resilient kid ? but we hope [Eeyore] comes back.

5. Andrew McGuire:

   Is the NRA down and out enough that United States can't muster an all-out assault on The CDC ? Or is that totally crazy thinking because the NRA can always muster any assault at any time ?